Theophylline, also known as 1,3-dimethylxanthine, is a phosphodiesterase inhibiting drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma under a variety of brand names. Pregnancy Category C Therapeutic actions. This job aid also provides an overview of the approved security classification documents that assist in analyzing and evaluating … These are plant alkaloids and components of coffee, tea and chocolate. Molecular Weight. Bronchial dilation and increase focus of contraction of diaphragmatic muscle. In the case of antipyrine derivatives demethylation reactions from the amino group induced by the hydroxyl radical were also … ... Ipratropium Bromide classification. A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. The major pharmacologic actions of the xanthines are inhibition of tissue phosphodiesterases which i … These medications open the airways, but they work on different receptors in the body. Theophylline relaxes bronchial smooth muscle by inhibition of the enzyme phosphodiesterase and suppresses airway responsiveness to stimuli that cause bronchoconstriction. Classifications of bronchodilators include beta 2-agonists, anticholinergics, and xanthine derivatives. Xanthine CAS registry number (Chemical Abstracts Service) 0000069-89-6. Clinical significance. Two xanthine derivatives with high affinity and high selectivity for adenosine A 1 receptor, 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) (Lohse et al., 1987) and its analog 8-dicyclopropylmethyl-1,3-dipropylxanthine (KF15372) (Shimada et al., 1991), were selected as lead compounds for in vivo imaging. 152. Therapeutic Categories. Anti-inflammatory. Decrease inflammation. As a member of the xanthine family, it bears structural and pharmacological similarity to theobromine … resulting from hydroxylation of Xanthine derivatives (uric acid derivatives) or demethylation products showed to be able to repair radicals resulting from adenine oxidation [12]. Indications The xanthine derivatives are agents that resemble natural occurring xanthines such as caffeine, theobromine and methylxanthines. 5.14 Xanthine Derivatives Open Resources for Nursing (Open RN) Theophylline is a xanthine derivative. Inhalation and Intranasal spray. 48:12.12 Xanthine Derivatives* 48:16 Expectorants 48:24 Mucolytic Agents* 48:36 Pulmonary Surfactants 48:48 Vasodilating Agents* 48:92 Respiratory Agents, Miscellaneous 52:00 Eye, Ear, Nose, and Throat (EENT) Preparations 52:02 Antiallergic Agents 52:04 Anti-infectives 52:04.04 Antibacterials 52:04.16 … Ipratropium Bromide administration. Anticholingeric Agent. Chemical Formula. Classification: Bronchodilator, Xanthine. Xanthine derivative Derivative Classification Training The purpose of this job aid is to provide quick reference information for the responsibilities and procedures associated with derivative classification. The increase in cAMP causes relaxation of bronchial smooth muscle. Mechanism of Action. Theophylline competitively blocks phosphodiesterase which increases cAMP tissue concentrations causing bronchodilatation, diuresis, CNS and cardiac stimulation, and gastric acid secretion. Xanthine DerivativesXanthine derivatives such as theophylline inhibit phosphodiesterase, resulting in an increase in cAMP. Xanthine derivatives Accession Number DBCAT001034 (DBCAT000503, DBCAT001028, DBCAT001220, DBCAT002203, DBCAT002692, DBCAT003295) Description. C5-H4-N4-O2. Derivatives of xanthine (known collectively as xanthines) are a group of alkaloids commonly used for their effects as mild stimulants and as bronchodilators, notably in the treatment of asthma or influenza symptoms. 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